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clevidipine butyrate
Cleviprex	Pharmaceutical company: The Medicines Company www.cleviprex.com

Pharmacologic classification: dihydropyridine calcium channel blocker
Therapeutic classification: antihypertensive
Pregnancy risk category: C

AVAILABLE FORMS
Injection: 0.5 mg/ml in 50- and 100-ml single-use vials

INDICATIONS AND DOSAGES
To lower blood pressure when oral therapy isn't feasible or desirable—
Adults: Begin infusion at 1 to 2 mg/hour and titrate by doubling the dose every 90 seconds. When blood pressure approaches goal, titrate every 5 to 10 minutes at less than double the dose. Maximum dose is 16 mg/ hour. Don't use beyond 72 hours.

CONTRAINDICATIONS AND CAUTIONS
Contraindicated in patients hypersensitive to soy beans, soy products, eggs, or egg products.
Contraindicated in those with defective lipid metabolism or severe aortic stenosis.
Use cautiously in patients with heart failure.

INTERACTIONS
None reported.

ADVERSE REACTIONS
CNS: headache.
CV: atrial fibrillation.
GI: nausea, vomiting.

Reactions may be common, uncommon, life-threatening, or COMMON AND LIFE-THREATENING.

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