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Meeting resistance in a PICC

If you feel resistance when you're instilling a drug into a peripherally inserted central catheter (PICC), aspirate and flush the PICC with sterile normal saline solution. In some cases, drug precipitate causes the blockage; remedy this by instilling another drug to alter the pH and bring the precipitate back into solution. If resistance persists, perform an X-ray if you suspect a kink, or administer thrombolytic therapy if you suspect a clot.
     
   

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